Life Sciences & Biotechnology
Title : | Therapeutic gene targeting by CRISPR-Cas system: advancement of editing platforms and proof-of-concept disease correction in patient derived cells |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Gene editing |
Principal Investigator : | Dr Debojyoti Chakraborty, Scientist, IGIB |
Timeline Start Year : | 2020 |
Timeline End Year : | 2025 |
Contact info : | souvik@igib. res. In |
Details
Executive Summary : | Objective: Creation of highly precise genome editing agents for therapeutic genome editing and their preclinical applications in disease models. Systematic elucidation of nucleic acid interrogation properties of genome editing proteins for improving gene correction. Peptide based delivery of CRISPR components. Establish a disease-specific and gene corrected isogenic control iPSC repository for monogenic diseases that afflict Indian population. Identification of New CRISPR-Cas Components from Microbial Genomes and Metagenomes of Various Niches from India. |
Organizations involved