Life Sciences & Biotechnology
Title : | Trapping glycation intermediates for the modulation of diabetes and its complications: a natural product derived therapeutic approach |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Diabetic Therapy |
Principal Investigator : | Dr P Jayamurthy, Senior Scientist, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Kerala |
Timeline Start Year : | 2020 |
Timeline End Year : | 2023 |
Contact info : | pjayamurthy@niist.res.in |
Details
Executive Summary : | Objective: Design a safe natural compound derived novel agents as inhibitor of AGE using preliminary assays ¦ To establish in vitro models of AGE production using methyl glyoxal intermediates as inducers, in L6 cells and validate efficacy of bioactives. To confirm the mechanism of inhibition of AGEs by the Lead analogue or its derivatives ¦ Validation of results using in vivo models |
Organizations involved