Life Sciences & Biotechnology
Title : | Understanding the mechanism of ICL (Inter crosslink) mediated replication collapse: involvement of Fanconi anemia proteins |
Area of research : | Life Sciences & Biotechnology |
Principal Investigator : | Dr. sudit s Mukhopadhyay, National Institute Of Technology (NIT) Durgapur, West Bengal |
Timeline Start Year : | 2023 |
Timeline End Year : | 2026 |
Contact info : | suditmukhopadhy@yahoo.com |
Equipments : | Microplate reader
Minor equipments
Tabletop shaking Incubator |
Details
Executive Summary : | Researchers are studying Fanconi anemia (FA), a rare genetic disorder linked to cancer, to understand the mechanisms of genomic instability. FA proteins repair DNA inter-crosslink damage through a unique pathway. Their previous project proposed a novel s-phase checkpoint pathway involving Fanconi anemia protein G. They found that mitomycin C-mediated ICL damage causes the ATR-mediated phosphorylation of serine 7 of FANCG, which is crucial for its interaction with MCM3AP. The researchers hypothesize that acetylation of MCM3 causes the dissociation of MCM3 from the chromatin, leading to the replication halt or s phase checkpoint. |
Co-PI: | Dr. subhankar RoyBarman, National Institute Of Technology (NIT) Durgapur, West Bengal-713209 |
Total Budget (INR): | 50,59,945 |
Organizations involved