Patents

DE2638047: Substituted 4 -acrylamidopodophyllotoxin congeners as antitumour antibiotics and process for the preparation thereof

The invention provides compounds of general formula (3) as useful potential antitumour agents against human cancer cell lines. The invention further provides a process for the synthesis of 4?-acrylamidopodophyllotoxin congeners of general formula (3), wherein R and R1 are an aryl group and R is selected from 3,4,5-trimethoxyphenyl or 2-methoxy phenyl and R1 is selected from the group consisting of 4-hydroxy-3-methoxyphenyl, 3-hydroxy-4-methoxyphenyl, 4-fluoro-3-methoxyphenyl, 3-fluoro-4-methoxyphenyl, 2-fluoro-5-methoxyphenyl, 2-fluoro-4-methoxyphenyl, 4-hydroxy-3-nitrophenyl, 4-methoxy-3-nitrophenyl, 4-nitrophenyl, 3-nitrophenyl, 2-nitro phenyl, 4-methoxyphenyl, 3-methoxyphenyl and 4-hydroxyphenyl.

Filing Date: 22-03-2013

Issue Date: 16-07-2014

Applicant: CSIR-Indian Institute of Chemical Technology (CSIR-IICT)

Patent No: DE2638047

Application No: 11719895

Inventor(s): Ahmed Kamal; Paidakula Suresh; Banala Ashwini Kumar; Adla Mallareddy; Papagari Venkat Reddy

Country: Germany

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