Patents

An improved process for the production of 3,4,5,6,7,8-hexahydro-1-(aryl methyl) isoquinolines

An improved process for the production of 3,4,5,6,7,8-hexahydro-l-(arylmethyl) isoquinolines of formula (2) wherein R is H or methoxy, which comprises stirring N-2-[l'- cyclohexenyl] ethyl-aryl autamide of formula (1) wherein R is H or methoxy group in an organic solvent with a Lewis acid and metal halide such as herein described at a temperature in the range of 0 to 80°C, for a period in the range of 4-12 hours, removing the solvent by distillation under reduced pressure ,treating the above said reaction mixture with ammonia solution, extracting the product using a water immiscible organic solvent, washing the organic layer with sodium thiosulphate solution ,and removing the solvent under reduced pressure to get compound of formula (2).

Filing Date: 01-11-2000

Issue Date: 25-04-2008

Patent No: IN217733 [India]

Application No: 963/DEL/2000

Inventor(s): Dilip Konwar; Birendra Nath Goswami; Naleen Borthakur

Licensing Option: Laboratory willing to jointly develop technology with industrial partner.

Implementing institute: CSIR-North East Institute of Science and Technology [CSIR-NEIST]

Funding agency: Council of Scientific and Industrial Research (CSIR)

IPC Classification: C07D 217/00

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