Patents

IN194589: A process for the preparation of chiral vicinal diolos using supported osmate

A process for the preparation of chiral vicinal diols using the supported osmate catalyst of the formula (S-NR3)2OSO4-NH2O wherein S is a support (resin or silica) containing charge balancing anions as herein described, R is an alkyl group (methyl, ethyl, propyl, butyl); n is the number of water molecules; the said, process comprises; assymetrically dihydroxylating the olefin of the kind as herein described in the presence of a cinchona alkaloid such as herein described in a solvent systems consisting of water and atleast one of acetone, acetonitrile and t-butanol in a ratio of 1:1 to 1:3, at a temperature in the range of -70 to 100°C for a period of 0.5 to 24 hrs in the presence of catalytic amount of supported osmate catalyst wherein the supported osmate is 0.01 to 10 mole % of osmium content with respect to substrate, recovering the pure vicinal diol by conventional method as here described.

Filing Date: 28-02-2002

Issue Date: 10-02-2006

Applicant: CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad

Patent No: IN194589

Application No: 0166DEL2002

Inventor(s): Choudary BM, Chowdari NS, Kantam ML, Raghavan KV

IPC Classification: A61K 31/02, A61K 31/045

Indian Classification: 55E4 ; 32F1

Country: India

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