Patents
The invention provides compounds of general formula (4a-z and 4aa-4ae) as useful potential antitumour agents against human cancer cell lines. It further provides a process for the synthesis of new 4-aza-2,3-didehydropodophyllotoxin compounds (4a-z and 4aa-4ae). R = 2,4 dimethoxy 5-pyrimidyl, 5-indyl,2-methyl-5-indyl,5-indazolyl, 6-benzthiazolyl,2-methyl-6-benzthiazolyl, 2-mercapto-5-imidazolyl, 5-triazolyl,3-(4-methoxyphenyl)5-isoxazolyl,3-(4-chlorophenyl)5-isoxazolyl,2,3,4-trimethoxyphenyl, R1 =3,4,5-trimethoxyphenyl,4-hydroxy-3-methoxyphenyl,3-hydroxy-4-methoxyphenyl,4-fluoro-3-methoxyphenyl,3-nitro-4-rnethoxyphenyl, 2-fluoro-4-methoxyphenyl