IN318030: 4 amino quinolines and process of preparation thereof

The invention relates the disclosure of 4-aminoquiniolines comprising preparation and antiplasmodial activity of chirally pure 7- chloro-N-(I-R-2-(4- alkylyl-piperazin- 1 -yl) ethyl)-4-aminoquinolines of formula-I where carbon no 1 of the side chain is  chiral and the substituent at position 1 of the side chain selected from the group comprising alkyl, aryl or aralkyl namely methyl,  benzyl, isopropyl, isobutyl etc. R1=H, CH2PH, CH2CH (CH3)2 CH2-indole, CH (CH3)CH2CH3, CH (CH3)2 CH (CH3) R2 = CH3  R3= Cl or CF3 Where n= l in the case of RI = CH2Ph. General formula I