IN341677: Synthesis of prodrugs of ibuprofen and nanoparticles preparation using poly (l-lactide) for controlled drug release

The invention discloses a process for the synthesis of alkyl ester prodrugs of Ibuprofen of formula (I) and its encapsulation with polymeric nanoparticles for controlled drug release. More particularly, the invention discloses a process for the synthesis of alkyl ester prodrugs of Ibuprofen of formula (I) from respective alcohols with increased pharmacological activity, low ulcerogenicity and good chemical stability. Further, the invention discloses the study of said drug in vitro and in vivo controlled release pattern.