IN341911: A highlyenantioselective synthesis of (+)-sertraline

The invention discloses substituted diphenyloxiranes and process for synthesis thereof.  The present invention also provides a process for production of enantiomerically pure anti - 3,3-diphenylmethyloxirane and  anti-3,3’-diphenylpropane-1,2-diol from racemic anti -3,3’-diphenylmethyloxirane using hydrolytic kinetic resolution. Further it provides a process for preparation of enantioselective (+) -Sertraline from anti - 3,3’ –dipheny lpropane-1,2-diol.