Description : | Chemotherapy constitutes an indispensable component of the cancer treatment. Since chemotherapeutic drugs are cytotoxic and one of the critical side effects of chemotherapy is myelosuppression associated neutropenia. Chemotherapy induced neutropenia could predispose cancer patients to fatal infections and multi-organ failure. Clinical management of neutropenia with administration ofGranulocyte-Colony Stimulating Factor (G-CSF) has played an instrumental role in improving the outcome of chemotherapy. However, administration of G-CSF leads to escalation in the cost of cancer management. G-CSF is also used for patients suffering from leucopenia, AIDS, sepsis and in bone-marrow transplantation.Furthermore,current research indicates multiple roles of G-CSF as a safe and efficacious drug, with potential of treating diseases beyond neutropenia. According to recent market survey,it is estimated that because of increasing demand of G-CSF, the market value of G-CSF would double in next five years.In the light of this information, we have developed G-CSF biosimilar and PEGylated G-CSF biosimilar. The G-CSF biosimilar technology is ready at the shake-flask level and we are working to develop the process for high-density fermentation. |