Research
Title : | Development of Novel Radical Trifluoromethoxylations to the Synthesis of Valuable Fluoro Synthons |
Area of research : | Chemical Sciences |
Focus area : | Fluorine Chemistry, Radical Reactions |
Principal Investigator : | Ms. Dodda Bhargavi, CSIR-Indian Institute Of Chemical Technology, Hyderabad, Telangana |
Timeline Start Year : | 2024 |
Timeline End Year : | 2026 |
Contact info : | doddabhargavi25@gmail.com |
Details
Executive Summary : | Fluoroalkyl groups are rapidly increasing due to the fluorine atom's unique features. The proposed project aims to incorporate trifluoromethoxy groups into organic molecules' strategic positions in cascade radical cyclization pathways, resulting in complex fluoro synthons like furans, pyrroles, coumamarines, and quinolones. The project will investigate reported radical trifluoromethoxy reagents and new sulphonamide-based trifluoromethoxy reagents. The concept will be used for late-stage trifluoromethoxy functionalization of natural products, with compounds screened for biological activity to identify potential drug candidates. |
Organizations involved
Implementing Agency : | CSIR-Indian Institute Of Chemical Technology, Hyderabad, Telangana Funding Agency :Anusandhan National Research Foundation (ANRF)/Science and Engineering Research Board (SERB) | Source :Anusandhan National Research Foundation/Science and Engineering Research Board (SERB), DST 2023-24 | |