Executive Summary : | This project work is aimed to synthesize adamantane derivative`s library consisting of amide, functional group starting from simple and commercially available cheap starting materials / Reagents. Because of the presence of only C and H atoms in adamantane building block, this structural unit is able to act as a lipophilic and hydrophobic bullet; thereby the bioavailability of the molecule will be enhanced. These molecules were designed to have better biomedical applications and photophysical applications due to the presence of multisite binding sites. Non covalent interactions such as hydrogen bonding is expected due to the presence of hydrogen donor binding site of amide functionality and lipohilic interactions due to the presence of adamantane moiety. The main focus will be directed to implement green chemical principles based synthetic strategies to achieve these novel adamantane derivatives. These greener synthetic strategies include the stabilization of one-pot synthesis (to avoid the purification of intermediates), multi-component reactions, highly atom economical processes, greener solvent (renewable, non hazardous, non flammable and non toxic) mediated and catalytic methods. In addition to this, chemo-selective reactions are to be focused under simple or milder reaction conditions (at room temperature and 1atm pressure). All these novel synthetic products are to be analyzed and characterized with advanced analytical methods such as NMR, IR, Mass, UV-Vis, HPLC, HRMs, Elemental analysis and X-ray studies. Different medicinal applications such as Antiviral, Antimalarial, Anticancer, Antifungal, Anti inflammatory and Antibacterial of these novel synthetic products were anticipated for these molecules. DFT studies will be carried out in order to achieve theoretical support to the experimental work and to obtain better analysis towards biomedical applications. |