Life Sciences & Biotechnology
Title : | Development and functional characterization of glycation resistant insulin for diabetic therapy |
Area of research : | Life Sciences & Biotechnology, Medical Sciences |
Focus area : | Diabetic therapy |
Principal Investigator : | Dr Mahesh J. Kulkarni, Scientist, CSIR-National Chemical Laboratory (CSIR-NCL), Pune |
Timeline Start Year : | 2020 |
Timeline End Year : | 2023 |
Contact info : | mj.Kulkarni@ncl.res.in |
Details
Executive Summary : | Objective: To produce glycation resistant proteoforms of insulin by site-directed mutagenesis of lysine and arginine residues. To evaluate the binding and activity of recombinant insulin in vitro by using biophysical and cell-based assays . To evaluate the in vivo efficiency, pharmocokinetics and immune response of recombinant insulin using diabetic rat model. To perform preclinical (toxicological studies) using diabetic rat models. |
Organizations involved