Executive Summary : | Alarming environmental pollution and its fallout has lead to the development of environmentally benign methodologies for the synthesis of biologically active compounds. Attempts are being made to develop eco-friendly, energy-efficient, cost-effective protocols for the synthesis of novel, potent drug molecules. synthesis of nitrogen heterocycles is one the most significant research areas in organic chemistry owing to their diverse biological activities. Triazoles and quinolines are some of those crucial nitrogen heterocycles. summing up the broad spectrum biological activities possessed by quinoline and triazole, there is considerable scope for the synthesis of hybrid analogs by incorporating triazole and quinoline nuclei. The quinolines containing triazole are the most significant class of bioactive compounds which play a very important role to inhibit the proliferation of cancer cells. synthetic methodologies involving magnetic nanoparticles supported by Cu-complex catalyst follow green chemistry principles. The synthesized magnetically supported Cu-complex provides an expeditious and cost-effective method to access quinolone-triazole hybrid molecules. Moreover, the use of heterogeneous Cu catalyst avoids contamination of biologically active quinolone-triazole with Cu(I) or Cu(II) salts. The developed method will prove to be very useful for the library synthesis of quinolone-triazole hybrid molecules. The Principal Investigator possesses strong research background and expertise in the field of proposed research topic. |