Research
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Title : | Development of NIR-III Absorbing Porphyrin-Thiadiazole Donor-Acceptor Macrocycles as Efficient Photothermal Conversion Agents |
Area of research : | Chemical Sciences |
Focus area : | Materials science |
Principal Investigator : | Dr. Neha Manav, Indian Institute of Technology (IIT) Delhi |
Timeline Start Year : | 2024 |
Timeline End Year : | 2026 |
Contact info : | neha[dot]manav[at]iitgn[dot]ac[dot]in |
Details
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Executive Summary : | The research aims to develop NIR-III (˃1500 nm) absorbing photothermal therapy (PTT) agents for deep-seated tumors. Current porphyrin-based PDT has limitations, including poor aqueous solubility, premature degradation, and short circulation time. The project aims to develop NIR-III absorbing PT agents using fused-porphyrin dimers coupled with strong acceptors through an acetylene bridge. The three principal objectives are to develop NIR-III absorbing PT agents, demonstrate superior photothermal conversion efficiency, and introduce phospho-lipid and cationic triphenylphosphine to improve bioavailability and selectivity. The project will involve several work packages, including synthesis, chemical characterization, formulation, photophysical characterization, electrochemical analysis, and in-vivo PTT studies. The project will significantly improve non-invasive cancer treatment using photothermal therapy in the NIR-III region, leading to better results and fewer side effects. |
Total Budget (INR): |
Organizations involved
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Implementing Agency : | Indian Institute of Technology (IIT) Delhi |
Funding Agency : | Anusandhan National Research Foundation (ANRF) or science and Engineering Research Board (sERB) |
Source : | science and Engineering Research Board (sERB), DsT |