Research

Life Sciences & Biotechnology

Title :

Development of therapeutic monoclonal antibodies against Chikungunya virus

Area of research :

Life Sciences & Biotechnology

Focus area :

Pharmaceutical Sciences

Principal Investigator :

Dr. Rajesh Kumar, Indian Institute of Technology(IIT) Roorkee, Uttarakhand (247667)

Timeline Start Year :

2024

Timeline End Year :

2026

Contact info :

Details

Executive Summary :

The proposal combines the expertise of India's Dr. Rajesh Kumar and Argentina's Dr. Diego E Alvarez, who have 13 years of experience in developing therapeutic monoclonal antibodies against infectious diseases. The team aims to develop reliable methods for mapping antibody specificities and transfer reagents and technical expertise between laboratories. The focus is on the Chikungunya virus, a major health concern in both countries, and the potential role of neutralizing antibodies (NAbs) in immunotherapy. The proposal will use a recombinant phage display approach to isolate monoclonal antibodies against the virus's E2 protein.

Co-PI:

Dr. Shailly Tomar, Indian Institute of Technology(IIT) Roorkee, Uttarakhand (247667)

Total Budget (INR):

8,18,000

Organizations involved