Life Sciences & Biotechnology
Title : | Exploration of Cyclic Diaryliodonium Salts as Biarylating Agents to Generate Medicinally Relevant Biaryl Scaffolds |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Neuroscience, Immunology |
Principal Investigator : | Dr. Mukesh Pasupuleti, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow, Uttar Pradesh |
Timeline Start Year : | 2023 |
Timeline End Year : | 2026 |
Contact info : | mukesh_p78@yahoo.com |
Details
Executive Summary : | Neurological disorders and age-related health issues are increasing rapidly, and despite extensive research, there are no effective therapies for chronic neurological diseases like Alzheimer's and Parkinson's. Neuroinflammation is recognized as a central mechanism, and immunomodulation therapy is considered a potential therapeutic strategy for neurological diseases. However, small molecules-based immunomodulatory drugs have not demonstrated their immune modulation effect in the brain due to their inability to pass through the blood-brain barrier or interact with brain-resident immune cells like microglia. The problem lies with the molecules, not the therapy. There is an urgent need to design new molecules that can pass through the blood-brain barrier and induce anti-inflammatory cytokines. Proteins involved in cellular homeostasis, when cleaved by proteases, generate cryptic host defense peptides (HDPs) with antimicrobial activities. This project aims to investigate whether cryptic HDPs induce cytokines expression in microglia, whether these responses reduce proinflammatory responses and enhance anti-inflammatory cytokines, and whether these responses are sequence-dependent. According to the "Antimicrobial Protection Hypothesis of Alzheimer's Disease," amyloid peptides defend the brain and central nervous system from microbe assault. Recent studies show that proinflammatory responses can inhibit neurogenesis, while anti-inflammatory cytokines can promote it. Therefore, it is crucial to explore the types of inflammatory responses generated in response to the interaction of cryptic HDP with microglia cells. This research could lead to further research on the role of pro or anti-inflammatory molecules inducers and neurological diseases, potentially translating the work into a commercially valuable product. |
Co-PI: | Dr. Jesu Arockiaraj, SRM Institute Of Science And Technology, Tamil Nadu-603203 |
Total Budget (INR): | 47,29,424 |
Organizations involved