Research
Title : | Identification of immunogenic peptide for diagnosis of orthohantavirus infection |
Area of research : | Medical Sciences |
Focus area : | Immunology and Infectious Disease Research |
Principal Investigator : | Dr. Manoj Baranwal, Thapar Institute of Engineering and Technology, Patiala, Punjab (147004), Dr. Sara Chandy, Kanchi Kamakoti Childs Trust Hospital, Childs Trust Medical Research Foundation (CTMRF) Chennai, Kerala (600034), Dr. Rohitha S Chandra, Lisie Medical and Educational Institutions, Kochi, Kerala (682019), Dr. Vinay Kumar, Thapar Institute of Engineering and Technology, Patiala, Punjab (147004) |
Contact info : | manoj.baranwal@thapar.edu; sarachandy@yahoo.co.in; rohithamahesh@gmail.com; vinay.kumar@thapar.edu; debajyoti.dutta@thapar.edu; knehank@gmail.com; priyankar.dey@thapar.edu; rahul.upadhyay@thapar.edu |
Details
Executive Summary : | The project aims to develop a diagnostic test system for Hemorrhagic fever with renal syndrome (HFRS), a common viral disease in India. The project involves the design of nucleocapsid and glycoprotein peptides containing immunodominant epitopes against Haantan HTNV, Thailand virus THAIV, and Puumala PUUV orthohantaviruses. The project also aims to diagnose orthohantavirus infection in patients with acute febrile illness, develop an artificial intelligence algorithm for epitope analysis, evaluate peptide-specific immune response in human samples, and design peptides HTNV, THAIV, and PUUV-based serological assays to detect multiple serotypes. The collaboration between the Russian and Indian teams provides an opportunity to develop serological tests detecting antibodies to unique orthoghantaviruses circulating in Tatarstan, Russia, and India. The study will further advance our understanding of orthohantavirus immunogenicity and help identify unique and cross-reacting epitopes. The collaboration between the Russian and Indian teams will also allow further exploration of immunologic cross reactivity between PUUV, HNTV, and THAIV orthohantaviruses in Russian HFRS serum and T cells. |
Co-PI: | Dr. Debajyoti Dutta, Thapar Institute of Engineering and Technology, Patiala, Punjab (147004), Ms. Neha Kaushal, Thapar Institute of Engineering and Technology, Patiala, Punjab (147004), Dr. Priyankar Dey, Thapar Institute of Engineering and Technology, Patiala, Punjab (147004), Dr. Rahul Upadhyay, Thapar Institute of Engineering and Technology, Patiala, Punjab (147004) |
Total Budget (INR): | 87,29,988 |
Organizations involved
Implementing Agency : | Thapar Institute of Engineering and Technology, Patiala, Punjab;
Kanchi Kamakoti Childs Trust Hospital, Childs Trust Medical Research Foundation (CTMRF) Chennai, Kerala;
Lisie Medical and Educational Institutions, Kochi, Kerala Funding Agency :Department of Science and Technology (DST) | Source :Department of Science and Technology (DST) | |