Life Sciences & Biotechnology
Title : | Investigating the role of therapeutic compounds in fermented foods and ethnic beverages used by the Tribal population of West Bengal as a novel therapy for Helicobacter pylori and H.pylori mediated gastric ulcer" |
Area of research : | Life Sciences & Biotechnology |
Principal Investigator : | Dr. Oindrilla MUkherjee, National Institute Of Technology (NIT) Durgapur, West Bengal |
Timeline Start Year : | 2023 |
Timeline End Year : | 2026 |
Contact info : | mukherjee.oindrilla@gmail.com |
Equipments : | pH Meter
Pipette set |
Details
Executive Summary : | Helicobacter pylori (Hp) is a Gram-negative, microaerophilic bacterium that colonizes the gastric mucosa, leading to gastritis and other associated diseases. Antibiotic therapies are increasingly associated with failure, and there is a rapid emergence of strains resistant to conventional antibiotics, particularly in developing countries. This has led to an urgent need for alternative treatments, as antibiotics eradicate non-pathogenic microbiota, disrupting the natural gut microbiota for some time after administration. The pathophysiology of Hp infection could provide crucial insights for probiotic development. Although Hp is prevalent in nearly 80% of the Asian population, only 10% of colonized individuals are at risk of developing peptic ulcers. The gastric microbiota also influences the pathogenic potential of Hp. Factors such as diet and host genetic background influence gut microbes' composition and activity. In ethnic communities of West Bengal, Hp prevalence is common, but Hp-associated disease is rare. Comparison of Hp strains has revealed no significant difference in virulence genes, and there is a lower risk of atrophy and metaplastic changes among the tribal population. Fermented foods have always been associated with probiotic effects, suggesting that they may restore gastric microbiota dysbiosis and prevent Hp-induced ulceration. The project aims to investigate therapeutic compounds of fermented foods as an alternative therapy for Hp. The work will identify and isolate the microbial composition of fermented foods and correlate them with metabolites released to obtain microbial and metabolome signatures. A microbial-derived metabolite host gene interaction will be explored to identify putative metabolites with protective roles in Hp-associated diseases. |
Co-PI: | Dr. Debjani Dutta, National Institute Of Technology (NIT) Durgapur, West Bengal-713209 |
Total Budget (INR): | 28,10,500 |
Organizations involved