Life Sciences & Biotechnology
Title : | Investigating the therapeutic potential of F2RL3-NLRP3 inflammasome axis modulation in ameliorating obesity induced fibro-inflammation |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Biochemistry |
Principal Investigator : | Dr. Rakhee Yadav, All India Institute of Medical sciences (AIIMs), New Delhi |
Timeline Start Year : | 2024 |
Timeline End Year : | 2027 |
Contact info : | y.rakhee@yahoo.com |
Details
Executive Summary : | Obesity-induced adipose tissue maladaptive response is primarily due to inflammation and fibrosis. Elevated F2RL3 protein in obese individuals could be a potential target to alleviate fibrosis and inflammation in adipose tissue. F2RL3 is activated by key effector proteases of coagulation and inflammatory pathways. In obesity, there is a hypercoagulable state with increased levels of prothrombotic molecules and a pro-inflammatory state with immune effectors activating F2RL3. The study aims to compare F2RL3 expression and influencers between obese and non-obese individuals, observe changes in inflammasome and fibrosis genes, and investigate if BMs-986120 can block the action of proteases from activating the F2RL3 receptor. This study will provide new insights into F2RL3 activation in obese individuals and its role in insulin resistance progression. |
Co-PI: | Dr. Archna singh, All India Institute of Medical sciences (AIIMs), New Delhi, Dr. Riyaz Ahmad Mir, All India Institute of Medical sciences (AIIMs), New Delhi, Prof. sandeep Aggarwal, All India Institute of Medical sciences (AIIMs), New Delhi |
Total Budget (INR): | 36,30,000 |
Organizations involved