Life Sciences & Biotechnology
Title : | Leishmaniasis: target specific approaches to affect host-pathogen interaction and disease process |
Area of research : | Life Sciences & Biotechnology, Medical Sciences |
Focus area : | Disease pathology |
Principal Investigator : | Dr Subrata Adak, Scientist, CSIR-Indian Institute of Chemical Biology (CSIR-IICB), Kolkata |
Timeline Start Year : | 2020 |
Timeline End Year : | 2025 |
Contact info : | director@iicb.res.in |
Details
Executive Summary : | Objective: Communication of anti-inflammatory signal from infected macrophage to neighboring cells: Effect on niche creation for Ld infection. Evaluating the potential of host derived Wnt in promoting resistance to Leishmania donovani infection. Cholesterol induced modulation of the leishmanial KMP-11 protein-macrophage interaction. Role of Leishmania derived linoleate in immunoregulation of macrophage. Role of Leishmania y-glutamyl cyclotransferase (ChaC) like protein in pathogenesis of this parasite. Understanding the genome fluidity during the process of gain or loss of virulence in Leishmania. |
Organizations involved