Executive Summary : | One-third of all in hospital patients, greater than 50% of all ICU patients and more than 80% of surgical ICU patients suffer from SIRS induced morbidity and mortality with diminishing chances of survival due to delayed diagnosis and poor prognosis. Microbial tests are time consuming and the currently available biochemical markers lack specificity and can detect only at later stages of sepsis. Thus, early diagnosis of SIRS in acute trauma patients is mandatory for effective management. In this project, a microfluidics based novel Lab on Chip (LOC) platform will be developed for continuous monitoring of vascular gasotransmitters with high selectivity, specificity and accuracy for detecting SIRS. The aim is also intended to understand the interrelationship between gasotransmitters, for studying the endothelial function and clinical outcomes in SIRS signaling. |
Co-PI: | Dr. Madhulika Dixit, Associate Professor, Indian Institute of Technology (IIT), Chennai, Paul Ramesh Thangaraj, Cardiothoracic Surgeon, Apollo Hospitals, Chennai, Muraleedharan K. M., Indian Institute of Technology (IIT), Chennai, Jayashree Gopal, Apollo Hospitals, Chennai, Anil Tarigopula, Apollo Hospitals, Chennai, Anil Prabhakar, Indian Institute of Technology (IIT), Chennai, Dr. Ananth Krishnan, Indian Institute of Technology (IIT), Chennai |