Life Sciences & Biotechnology
Title : | One-step stretchable PES laser scribed graphene IDEs for ultrasensitive non-enzymatic electrochemical sweat glucose detection |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Sensors and Biomedical Engineering |
Principal Investigator : | Dr. Geeta Bhatt, Birla Institute Of Technology and Science (BITS), Pilani, Rajasthan |
Timeline Start Year : | 2024 |
Timeline End Year : | 2026 |
Contact info : | geeta.bhatt@pilani.bits-pilani.ac.in |
Details
Executive Summary : | Glucose sensing is a very demanding field due to the alarming increase in diabetic cases. The research trends show that the sweat-based electrochemical impedance glucose detection methods are recently being adapted in a fast manner due to the highly integrable and miniaturizable nature of electrochemical impedance spectroscopy (EIS)-based sensing with painless detection method as compared to blood glucose detection method, which requires needle-pricking for glucose detection. Glucose detection can be carried out through enzymatic or non-enzymatic modes. Non-enzymatic glucose sensors perform way better than enzymatic ones in terms of sensitivity, durability, robustness, detection time, and cost. But still, the principle of detection needs continuous improvement to enhance the detection level efficiently to be able to detect very low levels of glucose, primarily in body fluids like sweat where glucose concentration is usually of the order of 0.06-0.2 mM as compared to corresponding blood glucose level (3.3-17.3 mM). Among the recent advancements, the utilization of Laser-induced graphene (LIG) electrodes for detection is gaining a lot of attention. LIG, which is emerging as a strong material for electrochemical sensing, is a highly porous 3D structure that offers several advantages of simple fabrication protocol, very high conductivity, and the largest surface area-to-volume ratio. The fabricated LIG electrodes are biodegradable in nature and hence do not cause any harm to the environment as well. Additionally, in terms of electrode design, interdigitated electrode (IDE) is a very adapted design, which provides the benefits of low ohmic losses and better signal capture capability and keeping these benefits in mind, in this research I propose to use IDE design using LIG for fabricating EIS-based non-enzymatic sweat glucose detector. Hence, the present research proposal proposes the fabrication of an ultrasensitive sweat glucose detection using LIG electrodes. The single-step stretchable LIG IDEs would be fabricated using poly(ether sulfone) (PES) membrane and would be further decorated with nickel and gold monolayers as nickel and its derivatives have presented a highly sensitive nature towards glucose sensing. This deposition would be primarily electroless in nature to not distort the fabricated platform's configuration but still observe a similar level of efficacy in it. Additionally, this monolayer deposition would help obtain a high signal-to-noise ratio and thus highly obtain improved detection sensitivity of the devised sensing platform. |
Total Budget (INR): | 28,82,299 |
Organizations involved