Executive Summary : | Fluorine, the most electronegative element, has gained significant attention in the synthetic organic community due to its ability to mimic the chemistry of hydrogen. Incorporating a fluorine atom into an organic molecule results in significant changes in physiochemical properties, including lowering pKa, increasing membrane permeability, modulating lipophilicity, resisting biological oxidation processes, controlling conformational biases, and biological or pharmacological properties. Over 20% of marketed drugs and agrochemicals are fluorinated molecules. Researchers have contributed significantly to synthesizing organic molecules with fluorine functionalities in the last two decades. Enamide 1, a structurally important moiety, is used as a synthetic building block for organic synthesis and exists in several biologically relevant molecules and natural products. The synthesis of functionalized enamide has gained special interest among research groups in the last decade, with ynamides 2 being used as a building block for direct synthesis. Anti-alpha, beta-difunctionalization of ynamides is feasible, while syn-alpha, beta-difunctionalization is challenging and less explored. The sahoo group has disclosed a series of regioselective syn-difunctionalization of ynamides as useful synthetic tools for synthesis of syn-alpha, beta-difunctionalized enamides. |