Life Sciences & Biotechnology
Title : | Strategies to ameliorate neurodegenerative disorders: mitochondria targeting agents for disease modifying role |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Mitochondrial bioenergetics for neurodegenerative disorders |
Principal Investigator : | Dr Shasi Vardhan Kalivendi, Scientist, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad |
Timeline Start Year : | 2020 |
Timeline End Year : | 2023 |
Contact info : | kalivendi@iict.res.in |
Details
Executive Summary : | Objective: WP 1: Synthesis of novel mitochondria targeted compounds of either synthetic or natural product origin using different side-chain linkers and evaluation of their efficacy on mitochondrial bioenergetics and biogenesis pathways in neuronal cells.
WP 2: Systematic evaluation of mitochondria targeted compounds for their ability to confer protection in appropriate cellular models of PD and AD.
WP 3: Toxicity and cerebral permeability studies of lead compounds.
WP 4: Evaluation of therapeutic potential of lead compounds in appropriate AD and PD mouse models. The current paradigm of drug discovery follows a simple principle, that a small molecule with appreciable specificity with minimum off-target affects and bioavailability. |
Organizations involved