Research

Life Sciences & Biotechnology

Title :

To study the effect of biotin supplementation to sperm wash media on the enhancement of sperm function

Area of research :

Life Sciences & Biotechnology, Computer Sciences and Information Technology

Focus area :

Bioinformatics

Principal Investigator :

Dr. Feroz Khan, Scientist, Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow

Timeline Start Year :

2014

Timeline End Year :

2016

Contact info :

Details

Executive Summary :

Identified potential inhibitors of Ask 1from PubChem database ny employing state of the art in silico methods in a pipeline. The 3D structutre of Ask1 protein was modeled, subsequently domain with potential binding site was idemtified i.e. D4. The D4 was subjected for 300ns long simulation ansd its native conformation was extracted after FEL analysis. Subsequently, rigrous docking, simulation of complexes, binding free energy calculation resulted, CIDs: as potential inhibitors of Ask1 subunit of Dam complex of C. albicans.

Publications :

 		2

Organizations involved

Implementing Agency :

Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, Uttar Pradesh 226015

Funding Agency :

Indian Council of Medical Research (ICMR), New Delhi

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