Computer Sciences and Information Technology
Title : | To study the effect of biotin supplementation to sperm wash media on the enhancement of sperm function |
Area of research : | Life Sciences & Biotechnology, Computer Sciences and Information Technology |
Focus area : | Bioinformatics |
Principal Investigator : | Dr. Feroz Khan, Scientist, Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow |
Timeline Start Year : | 2014 |
Timeline End Year : | 2016 |
Contact info : | f.khan@cimap.res.in |
Details
Executive Summary : | Identified potential inhibitors of Ask 1from PubChem database ny employing state of the art in silico methods in a pipeline. The 3D structutre of Ask1 protein was modeled, subsequently domain with potential binding site was idemtified i.e. D4. The D4 was subjected for 300ns long simulation ansd its native conformation was extracted after FEL analysis. Subsequently, rigrous docking, simulation of complexes, binding free energy calculation resulted, CIDs: as potential inhibitors of Ask1 subunit of Dam complex of C. albicans. |
Publications : | 2 |
Organizations involved