Research

Life Sciences & Biotechnology

Title :

To study gene expression for vitamin d receptor (VDR) and calcium sensing receptor (CaSR) in patients with primary hyperparathyroidism (PHPT) and its correlation with clinical outcome

Area of research :

Life Sciences & Biotechnology

Focus area :

Nutrition

Principal Investigator :

Dr. Sanjay Kumar Bhadada,  Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012

Timeline Start Year :

2010

Timeline End Year :

2012

Contact info :

Details

Executive Summary :

The present findings showed significant reductions in VDR mRNA expressions in adenomatous compared to normal parathyroid tissue. Consistent with these, immunohistochemistry also revealed reduction at both nuclear as well as cytoplasmic expression in adenoma cells.

Co-PI:

Dr. Madhu Khullar, Professor, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, Dr. Uma Nahar Saikia, Additional Professor, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, Dr. Naresh Sachdeva , Assistant Professor, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012

Achievements :

Research fellows 02

Publications :

 
3

PhD Produced :

1

Outcome/Output:

The present findings showed significant loss of CaSR expression at mRNA and protein level in parathyroid adenomas.

Organizations involved