Executive Summary : | This project focuses on the design, synthesis and utilization of novel amine based supramolecular cages (ABsCs), adorned with suitable functional groups, which upon modification circumvents different barriers of green chemistry. The newly synthesized ABsCs will be used for different green techniques like (i) catalysis, (ii) recognition, (iii) separation and (iv) bio-application. In this regard, several potential cavitands, mainly secondary and/or tertiary amine appended pi-cavity/fluorophoric group containing macrocycles (MCs) and macrobicycles (MBCs) will be synthesized and employed for- (i) Green photocatalysis/radical initiation by supramolecular cage (sCs) i.e., synthesis of green radical initiator from sCs and their use towards introduction of selectivity in photo-radical reaction; (ii) Green extractant of toxic ions/molecules by supramolecular cage i.e., synthesis of biodegradable ionic liquid from sCs and their use towards extraction of toxic anions from waste water and conversion of those anions into chemically utilizable form; (iii) Bio-applications of novel supramolecular cages i.e., design and synthesis of fluorophore appended macrobi/tricycles for drug delivery and study of them towards drug delivery. In more specific way, efforts will be made towards sustainable photochemical reactions with selectivity like -COOH group for decarboxylation, C-H bonds for C-H activation, benzylic-CH2 group for oxidation etc. NMR, IR, MAss, HPLC will be utilized for the evaluation of yield and purity of the products. solution state binding properties as well selectivity pattern of the receptors will be evaluated using NMR, UV-Vis, Fluorescence, Time resolved spectroscopy etc. whereas, solid state study will be carried out using single crystal X-ray diffraction technique. |