Research

Computer Sciences and Information Technology

Title :

Surface Engineering of Biomedical Implants for the Prevention of MDR Infection

Area of research :

Communication Engineering, Computer Sciences and Information Technology

Focus area :

Antimicrobial Strategies

Principal Investigator :

Dr. Selvakumar Murugesan, National Institute Of Technology, Mangalore, Karnataka, 575025

Timeline Start Year :

2023

Timeline End Year :

2026

Contact info :

Details

Executive Summary :

Bacterial infections in biomedical implants cause severe damage and lead to implant failure, surgery, and re-implantation. Current antibiotics are ineffective due to their limited ability to reach damaged tissue, MDR development by bacteria, and toxic side effects. A new project aims to develop a novel coating formulation using natural polyphenol tannic acid, engineered spider silk protein, and 2D-nanomaterial MXenes for synergistic triple-mode antibacterial action. The formulation will be extended to scaffolds and studied for biofilm formation and antimicrobial characteristics using various assays. This will lead to a universal low-cost coating technology for various medical substrates.

Total Budget (INR):

44,34,400

Organizations involved