Research
Title : | Targeting two diseases with one stone Inhibition of enzyme modulators of androgen receptor function in prostate cancer and COVID-19 |
Area of research : | Material Sciences, Other Areas |
Focus area : | Molecular Biology |
Principal Investigator : | Dr. Md Imtaiyaz Hassan, Jamia Milia Islamia, Central University, New delhi, (110025) |
Timeline Start Year : | 2023 |
Timeline End Year : | 2026 |
Contact info : | mihassan@jmi.ac.in,singhs@nccs.res.in |
Details
Executive Summary : | This project aims to identify compounds that disrupt androgen receptor AR-signaling, which is the standard treatment for prostate cancer. By targeting specific proteins, such as AKR1C and PIM1 isoforms, the efficacy of cancer treatments may be improved. The project also suggests that AR-signaling drugs could be repurposed for COVID-19 treatment, as AR regulates the serine protease TMNPRSS2 in various tissues, including the lungs. This could potentially reduce the risk of SARS-CoV2 infection in men receiving androgen deprivation therapy. |
Co-PI: | Dr. Shailza Singh, National Centre for Cell Sceince, Pune, Maharashtra (411007) |
Total Budget (INR): | 12,15,000 |
Organizations involved
Implementing Agency : | Jamia Milia Islamia, Central University, New delhi Funding Agency :Department of science and Technology (DST) | |