Life Sciences & Biotechnology
Title : | Transgenerational effect of paternal and maternal vitamin B12 deficiency |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Study of vitamin deficiency in animal model |
Principal Investigator : | Dr Shantanu Sengupta, Scientist, CSIR-Institute of Genomics & Integrative Biology (CSIR-IGIB), New Delhi |
Timeline Start Year : | 2020 |
Timeline End Year : | 2023 |
Contact info : | shantanus@igib.res.in |
Details
Executive Summary : | Objective: Determine the changes in epigenetic modification, transcriptomic, proteomic and metabolomic profile in Liver and skeletal muscle in pups born to paternal vitamin B 12 deficient rats. To evaluate if vitamin B12 deficiency induced alteration of lipid levels are directly mediated by PPAR a. Compare the pathways and processes affected by maternal and paternal vitamin B 12 deficiency and identify the commonality or differences there of to find a common/differential mechanism for the phenotypic changes. |
Organizations involved