Life Sciences & Biotechnology
Title : | Understanding the mechanism of osteopreia and aberrant bone formation, and discovery of new targets for skeletal medicine (Osteo Target) |
Area of research : | Life Sciences & Biotechnology, Medical Sciences |
Focus area : | Skeletal medicine |
Principal Investigator : | Dr Naibedya Chattopadhyay, Scientist, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow |
Timeline Start Year : | 2020 |
Timeline End Year : | 2025 |
Contact info : | director@cdri.res.in |
Details
Executive Summary : | Objective: Identification of sclerostin-derived peptides with the ability to inhibit the Wntsignaling pathway and characterization of their bone-growth inhibiting properties b) To examine in vivo activity of such peptides for investigating their efficacy in an osteoarthritis animal model c) To identify sclerostin-derived peptides as its inhibitors d) To characterize if these sclerostin-inhibitors can induce bone growth/formation in vitro experiments e) To examine if these sclerostin-inhibitors can induce both growth/formation in vivo animal model f) Understanding the mode of action and structural studies on these sclerostin-mimetic and sclerostin-inhibitory peptides g) PK, stability studies and regulatory (IND-enabling) studies of the lead peptides. |
Organizations involved