Life Sciences & Biotechnology
Title : | Modulation of protein aggregation by excipients designed with high specificity for the misfolded states |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Exponential Technologies |
Principal Investigator : | Prof. Anurag Singh Rathore, Indian Institute Of Technology (IIT) Delhi |
Timeline Start Year : | 2023 |
Timeline End Year : | 2026 |
Contact info : | asrathore@biotechcmz.com |
Details
Executive Summary : | The researchers are developing an integrated approach to design dendrimers that can bind to aggregation-prone partially folding intermediates (PFIs) with high specificity and inhibit early protein aggregation stages. The approach will incorporate inputs from structural bioinformatics, organic chemistry, biophysical, and biological characterization. The dendrimers will inhibit cytotoxic oligomers and complement existing excipients, which modulate fibril growth. Insulin will be chosen as a model protein due to its high therapeutic relevance and available experimental data. The design will use hotspot residues at the binding interface as templates, complementing protein interaction hotspots. The dendrimers will be synthesized, characterized, and tested in animal models to establish their safety and efficacy. |
Co-PI: | Dr. Gaurav Goel, Indian Institute Of Technology (IIT) Delhi-110016, Dr. V Haridas, Indian Institute Of Technology (IIT) Delhi-110016, Dr. Sarika Gupta, National Institute Of Immunology, New Delhi-110067 |
Total Budget (INR): | 67,83,990 |
Organizations involved