Life Sciences & Biotechnology
Title : | Studies of antioxidative and immunomodulatory effect of conjugated linolenic acid from bitter gourd oil |
Area of research : | Life Sciences & Biotechnology |
Focus area : | Nutrition |
Principal Investigator : | Dr. Pubali Dhar, Professor, University of Calcutta (UC), Kolkata |
Timeline Start Year : | 2011 |
Timeline End Year : | 2014 |
Contact info : | pubaligoshdhar@yahoo.com;
pkbbioc@caluniv.ac.in;
prasantabag@gmail.com |
Details
Executive Summary : | The mode of CLnA implementation in the biological models was modified to nanoemulsion and conventional formulations for better absorption, lesser auto-oxidation and providing technological dimension for pragmatic and clinical relevance. Methodology developed can also be commercialized as a low cost high impact technology for similar studies on bioactive lipids. Emphasis was laid on providing empirical evidence to establish the positive implications of nano-sized CLnA formulations which showed higher efficacy over micron-sized systems, irrespective of the fact that the composition of all the formulations was maintained constant. Additionally, real-time flow cytometric data was provided to show that nano-sized bioactive lipids, CLnA, are rapidly internalized and metabolized with enhanced prophylactic and therapeutic effects than micron-sized CLnA. |
Co-PI: | Dr. Prasanta K Bag, Professor, University of Calcutta (UC), Kolkata |
Outcome/Output: | The results of the study showed that the optimum dosage values for feeding of lipid nano/micro emulsions have been standardized to counter-alloxan induced diabetes in Charles foster strain rats. |
Organizations involved